Pipeline & Proof of Concept
Our robust and growing pipeline has the potential to play a critically influential role in the practice of Gut Microbiome Medicine and create significant value for patients and shareholders.
CS Therapeutic Pipeline
Therapeutic area
Gastroenterology / Infectious Disease
Oncology
Indication
POC*
DISCOVERY
PRECLINICAL
Phase I
Phase II
Phase III
Surgical Site Infection / Anastomotic Leak
Inflammatory Bowel Disease
Sepsis
C. Diff. / C. Diff. Recurrence
CS-0003, Phase I in 2027
CS-0003, Preclinical POC underway
CS-0003
CS-0003
Colon Cancer Recurrence
Chemotherapy-related Toxicities and Infections
Radiation Toxicities
CS-0003
CS-0003, non-dilutive grant R&D
CS-0003
The study is in progress.
Highlighted Proof of Concept Publications Below:
Anastomotic Leak
SSI via Trojan Horse Mechanism
Sepsis
- Phosphate-Containing Polyethylene Glycol Polymers Prevent Lethal Sepsis by Multidrug-Resistant Pathogens; Antimicrob Agents Chemother; Feb 2014
- Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts; mBio; 30 July 2019
Colon Cancer Recurrence
- Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation Following Colorectal Surgery; Gastroenterology; 01 Mar 2020
- Western Diet-induced Transcriptional Changes in Anastomotic Tissue is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery; Ann Surg; 01 Dec 2023
Thought Leadership
- Surgical Site Infection
- Social determinants of health, the microbiome, and surgical injury; J Trauma Acute Care Surg; 01 July 2024
- Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship; JAMA Surg; 01 Aug 2024
- Rationale behind phosphate therapy to modulate the gut microbiome and protect against surgery-related infection; Microbiota Host; Feb 2023
- Anastomotic Leak
- Anastomotic Leak: Toward an Understanding of Its Root Causes; J Gastrointest Surg; Nov 2021
- Sepsis
- Sepsis and the Microbiome: A Vicious Cycle; J Infect Dis; 16 June 2021
Dr. Eugene Chang’s NIH-funded lab, the Chang Lab at the University of Chicago in collaboration with The University of Chicago Duchossois Family Institute produced the GB diagnostic technology platform.
GB: GI Discovery Platform
Therapeutic area
Gut Microbiome Function
Use Cases
Potential Partners
Adult Gut Health (18+)
Surgical Site Infection / Anastomotic Leak Risk
IBD Patient Stratification
DFI, Mayo Clinic, UGH (Optum), Kroger
Internal development
J&J, AbbVie, Takeda, Merck, Pfizer, Eli Lilly
Unmet need and thought leadership:
- The unmet need for a validated, FDA approved microbiome diagnostic test
- Assessing the health of the gut microbial organ: why and how?; The Journal of Clinical Investigation; 2025
- International consensus statement on microbiome testing in clinical practice; Lancet Gastroenterol Hepatol; 05 Dec 2024
- The DCT microbiome testing industry needs more regulation; Science; 14 Mar 2024
- The importance of the gut microbiome to human health
- Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects; Cell; 06 June 2025
- Diet outperforms microbial transplant to drive microbiome recovery in mice; Nature; 30 April 2025
- The Gut Microbiome: Reaching the Promise Through Discovery— Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine; Gastroenterology; Jan 2021
- Microbial metabolites in health and disease: Navigating the unknown in search of function; J Biol Chem; 07 Apr 2017
- Role of the gut microbiome in inflammatory bowel disease
- The Gut Microbiome and Inflammatory Bowel Diseases; Annu Rev Med; 27 Jan 2022
- Inflammatory Bowel Diseases and the Microbiome: Searching the Crime Scene for Clues; Gastroenterology; Jan 2021
- Importance of the Early Life microbiome
- Microbiota-dependent early-life programming of gastrointestinal motility; iScience; 06 Sept 2024
- Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10−/− mice; Gastroenterology; 01 Sept 2021