Pipeline & Proof of Concept
Our robust and growing pipeline has the potential to play a critically influential role in the practice of Gut Microbiome Medicine and create significant value for patients and shareholders.
Dr. Eugene Chang’s NIH-funded lab, the Chang Lab at the University of Chicago in collaboration with The University of Chicago Duchossois Family Institute produced the GB diagnostic technology platform.
Therapeutic area
Gut Microbiome
Functional Health
GI Disease Management
Indication
POC*
DISCOVERY & IDEATION
INVENTION & PROTOTYPING
PRECLINICAL
CLINICAL
Regulatory Decision
Adults (ages 18-64)
Early Childhood Development (0-5)
Older Adult Longevity (ages 65+)
GB-0001
GB-00XX
GB-00XX
Irritable Bowel Syndrome (IBS)
IBD Patients Mangement / Biological Therapy
C. diff (Clostridioides difficile)
GB-0001
GB-00XX
GB-00XX
Unmet need and thought leadership:
- The unmet need for a validated, FDA approved microbiome diagnostic test
- Assessing the health of the gut microbial organ: why and how?; The Journal of Clinical Investigation; 2025
- International consensus statement on microbiome testing in clinical practice; Lancet Gastroenterol Hepatol; 05 Dec 2024
- The DCT microbiome testing industry needs more regulation; Science; 14 Mar 2024
- The importance of the gut microbiome to human health
- Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects; Cell; 06 June 2025
- Diet outperforms microbial transplant to drive microbiome recovery in mice; Nature; 30 April 2025
- The Gut Microbiome: Reaching the Promise Through Discovery— Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine; Gastroenterology; Jan 2021
- Microbial metabolites in health and disease: Navigating the unknown in search of function; J Biol Chem; 07 Apr 2017
- Role of the gut microbiome in inflammatory bowel disease
- The Gut Microbiome and Inflammatory Bowel Diseases; Annu Rev Med; 27 Jan 2022
- Inflammatory Bowel Diseases and the Microbiome: Searching the Crime Scene for Clues; Gastroenterology; Jan 2021
- Importance of the Early Life microbiome
- Microbiota-dependent early-life programming of gastrointestinal motility; iScience; 06 Sept 2024
- Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10−/− mice; Gastroenterology; 01 Sept 2021
CS Therapeutic Platform Technology Pipeline:
Therapeutic area
Infectious Diseases
Oncology
Indication
POC*
DISCOVERY
PRECLINICAL
Phase I
Phase II
Phase III
Surgical Site Infection
Sepsis
Wound Site Virulence Suppression
CS-0003
CS-0003
CS-00XX
Colon Cancer Recurrence
Chemotherapy Related Toxicities and Infections
CS-00XX
CS-00XX
The study is in progress.
Highlighted Proof of Concept Publications Below:
Anastomotic Leak
SSI via Trojan Horse Mechanism
Sepsis
- Phosphate-Containing Polyethylene Glycol Polymers Prevent Lethal Sepsis by Multidrug-Resistant Pathogens; Antimicrob Agents Chemother; Feb 2014
- Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts; mBio; 30 July 2019
Colon Cancer Recurrence
- Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation Following Colorectal Surgery; Gastroenterology; 01 Mar 2020
- Western Diet-induced Transcriptional Changes in Anastomotic Tissue is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery; Ann Surg; 01 Dec 2023
Thought Leadership
- Surgical Site Infection
- Social determinants of health, the microbiome, and surgical injury; J Trauma Acute Care Surg; 01 July 2024
- Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship; JAMA Surg; 01 Aug 2024
- Rationale behind phosphate therapy to modulate the gut microbiome and protect against surgery-related infection; Microbiota Host; Feb 2023
- Anastomotic Leak
- Anastomotic Leak: Toward an Understanding of Its Root Causes; J Gastrointest Surg; Nov 2021
- Sepsis
- Sepsis and the Microbiome: A Vicious Cycle; J Infect Dis; 16 June 2021
