Pipeline & Proof of Concept

Our robust and growing pipeline has the potential to play a critically influential role in mucosal immune science and create significant value for patients and shareholders.

CS Therapeutic Pipeline

Therapeutic area

Gastroenterology / Infectious Disease

Oncology

Indication

POC*

DISCOVERY

PRECLINICAL

Phase I

Phase II

Phase III

Surgical Site Infection / Anastomotic Leak

Inflammatory Bowel Disease

Sepsis

C. Diff. / C. Diff. Recurrence

CS-0003, Phase I in 2027

CS-0003, Preclinical POC underway

CS-0003

Colon Cancer Recurrence

Chemotherapy-related Toxicities and Infections

Radiation Toxicities

CS-0003

CS-0003, non-dilutive grant R&D

CS-0003

The study is in progress.

Highlighted Proof of Concept Publications Below:

Anastomotic Leak

Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model; Br J Surg; 16 Apr 2018

SSI via Trojan Horse Mechanism

Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the “Trojan Horse Hypothesis”; Ann Surg; Apr 2018
A Novel Nonantibiotic Gut-directed Strategy to Prevent Surgical Site Infections; Ann Surg; 01 Sept 2022

Sepsis

Phosphate-Containing Polyethylene Glycol Polymers Prevent Lethal Sepsis by Multidrug-Resistant Pathogens; Antimicrob Agents Chemother; Feb 2014
Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts; mBio; 30 July 2019

Colon Cancer Recurrence

Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation Following Colorectal Surgery; Gastroenterology; 01 Mar 2020
Western Diet-induced Transcriptional Changes in Anastomotic Tissue is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery; Ann Surg; 01 Dec 2023

Thought Leadership

Surgical Site Infection
- Social determinants of health, the microbiome, and surgical injury; J Trauma Acute Care Surg; 01 July 2024
- Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship; JAMA Surg; 01 Aug 2024
- Rationale behind phosphate therapy to modulate the gut microbiome and protect against surgery-related infection; Microbiota Host; Feb 2023
Anastomotic Leak
- Anastomotic Leak: Toward an Understanding of Its Root Causes; J Gastrointest Surg; Nov 2021

Sepsis
- Sepsis and the Microbiome: A Vicious Cycle; J Infect Dis; 16 June 2021

Dr. Eugene Chang’s NIH-funded lab, the Chang Lab at the University of Chicago in collaboration with The University of Chicago Duchossois Family Institute produced the GB diagnostic technology platform.

GB: GI Discovery Platform

Therapeutic area

Gut Microbiome
Function

Use Cases

Potential Partners

Adult Gut Health (18+)

Surgical Site Infection / Anastomotic Leak Risk

IBD Patient Stratification

DFI, Mayo Clinic, UGH (Optum), Kroger

Internal development

J&J, AbbVie, Takeda, Merck, Pfizer, Eli Lilly

Unmet need and thought leadership:

The unmet need for a validated, FDA approved microbiome diagnostic test
- Assessing the health of the gut microbial organ: why and how?; The Journal of Clinical Investigation; 2025
- International consensus statement on microbiome testing in clinical practice; Lancet Gastroenterol Hepatol; 05 Dec 2024
- The DCT microbiome testing industry needs more regulation; Science; 14 Mar 2024

The importance of the gut microbiome to human health
- Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects; Cell; 06 June 2025
- Diet outperforms microbial transplant to drive microbiome recovery in mice; Nature; 30 April 2025
- The Gut Microbiome: Reaching the Promise Through Discovery— Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine; Gastroenterology; Jan 2021
- Microbial metabolites in health and disease: Navigating the unknown in search of function; J Biol Chem; 07 Apr 2017

Role of the gut microbiome in inflammatory bowel disease
- The Gut Microbiome and Inflammatory Bowel Diseases; Annu Rev Med; 27 Jan 2022
- Inflammatory Bowel Diseases and the Microbiome: Searching the Crime Scene for Clues; Gastroenterology; Jan 2021

Importance of the Early Life microbiome
- Microbiota-dependent early-life programming of gastrointestinal motility; iScience; 06 Sept 2024
- Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10−/− mice; Gastroenterology; 01 Sept 2021

Pipeline & Proof of Concept

Therapeutic area

Gastroenterology / Infectious Disease

Oncology

Indication

POC*

DISCOVERY

PRECLINICAL

Phase I

Phase II

Phase III

Surgical Site Infection / Anastomotic Leak

Inflammatory Bowel Disease

Sepsis

C. Diff. / C. Diff. Recurrence

CS-0003, Phase I in 2027

CS-0003, Preclinical POC underway

CS-0003

CS-0003

Colon Cancer Recurrence

Chemotherapy-related Toxicities and Infections

Radiation Toxicities

CS-0003

CS-0003, non-dilutive grant R&D

CS-0003

Highlighted Proof of Concept Publications Below:

Therapeutic area

Gut Microbiome Function

Use Cases

Potential Partners

Adult Gut Health (18+)

Surgical Site Infection / Anastomotic Leak Risk

IBD Patient Stratification

DFI, Mayo Clinic, UGH (Optum), Kroger

Internal development

J&J, AbbVie, Takeda, Merck, Pfizer, Eli Lilly

Unmet need and thought leadership:

Gut Microbiome
Function